Differin
Differin Adapalene Gel 0.1% Acne Treatment
Key Features
- FDA-approved retinoid that increases cell turnover
- Per the brand: treats blackheads, whiteheads, pimples, and clogged pores
- Per the brand: oil-free, fragrance-free gel formula
- Per the brand: reduces redness and inflammation
- Pump dispenser for measured application
1% is an over-the-counter retinoid treatment that contains adapalene, a prescription-strength active ingredient approved by the FDA.
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From
$15.49
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Last price update was: Sep 11, 2026, 4:49 AM
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Highlights
Description
Differin Adapalene Gel 0.1% is an over-the-counter retinoid treatment that contains adapalene, a prescription-strength active ingredient approved by the FDA. The brand describes it as a lightweight, oil-free gel designed to treat and help prevent breakouts, blackheads, whiteheads, and blemishes across all skin types. Per the brand, adapalene works by increasing cell turnover to address two main causes of acne: clogged pores and inflammation.
Per the brand, the formula is fragrance-free and non-comedogenic. The brand claims it reduces redness and inflammation caused by acne and restores skin texture and tone. The product comes in a pump bottle for measured application. In clinical studies cited by the brand, the product provided up to an 87% reduction in acne lesions after 12 weeks of consistent use, with continued improvement with further use.
Adaptalene can increase skin sensitivity to sunlight, so the brand recommends using sunscreen and protective clothing during the day, especially if you normally get high sun exposure or have sensitive skin. During the early weeks of use, acne may appear to worsen before it improves, which is normal according to the brand. Apply a thin layer to clean, dry skin once daily, and the brand recommends consistent use for 12 weeks to see best results.
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How to use
- Cleanse affected areas with a mild, non-irritating cleanser and pat dry.
- Apply a thin layer of gel to the entire affected area once a day.
- Use consistently for 12 weeks for best results.
- Avoid the eyes, lips, angles of the nose, and mucous membranes.
- Use sunscreen and protective clothing during the day, as adapalene increases sun sensitivity.
Good to know
- Per the brand, this is designed for acne-prone skin and all skin types; it's for adults and suitable for use by men and women.
- During early weeks, acne may appear to worsen before it improves; continue use unless irritation becomes severe.
- Per the brand, apply once daily at night or during the day, but not both, to help mitigate irritation.
- Do not use on damaged skin, cuts, abrasions, eczema, or sunburned areas.
- Do not wax hair in areas where you've applied the product.
- If pregnant or breastfeeding, consult a doctor before use.
FAQs
How long does it take to see results?
Per the brand, you should use the product consistently for 12 weeks for best results. In clinical studies cited by the brand, the product provided up to an 87% reduction in acne lesions after 12 weeks, with continued improvement with further use.
Can I use this during the day?
Yes, you can apply Differin Gel during the day or at night, but not both. However, you must use sunscreen and protective clothing during the day because adapalene increases sensitivity to sunlight.
What size is this product?
This is a travel size. The brand sells Differin Adapalene Gel in 15g and 45g sizes.
Does it contain fragrance or alcohol?
No. Per the brand, the formula is fragrance-free and does not contain alcohol or oils.
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